cenobamate will enhance the degree or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Intently. Take into consideration a dose reduction of CYP2C19 substrates, as clinically proper, when utilised concomitantly with cenobamate.
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modafinil will reduce the extent or effect of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Potent or moderate CYP3A4 inducers may possibly increase charge of diazepam elimination; as a result, efficacy of diazepam may very well be decreased.
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modafinil will minimize the level or influence of pacritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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Keep track of Intently (one)crofelemer boosts levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Crofelemer has the probable to inhibit CYP3A4 at concentrations anticipated from the intestine; unlikely to inhibit systemically mainly because minimally absorbed.
crofelemer will increase amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the likely to Buy Modalert inhibit CYP3A4 at concentrations expected in the gut; not likely to inhibit systemically simply because minimally absorbed.
mitotane decreases levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a powerful inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for possible dosage changes.
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Stiripentol is often a CYP3A4 inhibitor and inducer. Check CYP3A4 substrates coadministered with stiripentol for increased or lowered effects. CYP3A4 substrates may well need dosage adjustment.
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